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Generic Name: Calcitriol 0.25mcg
Manufacturer/Distributor: Drug International Ltd.
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✅ Description:
Indications of Dicaltrol
Conditions requiring a combination of Calcium and Calcitriol include Osteoporosis, Hypoparathyroidism, Hypocalcaemia, Osteomalacia Rickets, and Renal Osteodystrophy.
Pharmacology
Calcium salt can help prevent and treat calcium deficiency and negative calcium balance. It is also used as a supplement to aid in the prevention and treatment of osteoporosis.
Calcitriol raises serum calcium levels by promoting calcium absorption in the intestines and kidney retention. It also promotes phosphate resorption in the renal tubules, which reduces serum phosphatase, PTH, and bone resorption
Dosage & Administration of Dicaltrol
- 0.25 mcg/day or every other day for hyperparathyroidism in renal failure. may gradually rise.
- 0.5-2 mcg once daily for hypoparathyroidism or pseudohypoparathyroidism.
- Rickets caused by a lack of vitamin D: 0.015–0.02 mcg/kg/day. 0.03-0.06 mcg/kg/day for maintenance. 2 mcg maximum daily.
- Dialysis patients with hyperparathyroidism receive 0.5–4 mcg three times per week. Maximum: 8 mcg three times per week.
- 0.5 mcg three times per week for hyperparathyroidism in renal failure, with possible increases of 0.25 to 0.5 mcg every 2-4 weeks. 3 times per week, 0.5–3 mcg for maintenance.
Interaction of Dicaltrol
Thiazide diuretics or vitamin D can cause milk-alkali syndrome and hypercalcemia when taken together. Absorption is reduced as a result of corticosteroids. Reduced absorption is observed for tetracyclines, atenolol, iron, quinolones, alendronate, Na fluoride, zinc, and calcium-channel blockers. increases the heart's sensitivity to the effects of digitalis glycosides and may cause digitalis intoxication.
Contraindications
Hypercalcemia, vitamin D toxicity, pregnancy, and lactation
Side Effects
- Polyuria
- Polydipsia
- Anorexia
- Irritability
- Weight loss
- Nocturia
- Mild acidosis
- Reversible azotemia
- Generalized vascular calcification
- Nephrocalcinosis
- Conjunctivitis (calcific)
- Pancreatitis
- Photophobia
- Rhinorrhoea
- Pruritus
- Hyperthermia
- Decreased libido
Pregnancy & Lactation
Pregnancy Classification: Although animal reproduction studies have shown that the drug has a negative effect on the fetus, and there are no adequate and well-controlled human studies, the drug's potential benefits may justify its use in pregnant women despite the risks.
Precautions & Warnings
Hypercalcemia is caused by an unknown cause. Pediatric doses must be tailored to the individual child and closely monitored by a physician. Coronary artery disease, renal impairment, and arteriosclerosis are all common in the elderly. Hypoparathyroidism.
Storage Conditions
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.
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